Objective: To evaluate the effect of Senqi Xiaobi(SQ) granules on serum levels of growth hormone(GH)

epidermal growth factor(EGF) and gastrin (GAS) in rats with chronic atrophic gastritis (CAG). Method: CAG model was established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and other comprehensive factors for 14 weeks. Then the model rats were divided into 6 groups randomly

which were ig administered with saline

Moluodan

folic acid

SQ granules 2

4

8 g·kg-1

respectively

taking normal Wistar rats as control group at the beginning of modeling. Body weight of rats was observed for 22 weeks. In 22nd week

the pathological changes of gastric mucosa were observed

serum levels of GH

EGF GAS were measured by radioimmunoassay. Result: in 22nd week

in the model group

there were typical CAG pathological morphological changes on the gastric mucosa

Compared with model group

there were improvements on pathological changes at different degrees in the SQ Granules-treated groups; serum levels of GH in the SQ Granules 8 g·kg-1 group were significantly higher than that in the model group[(5.42±0.68)

(5.02±0.71 μg·L-1

P<0.05)];serum levels of EGF in the SQ granules 4

2 g·kg-1 group were significantly higher than that in the model group[(0.88±0.22)

(0.86±0.18)

(0.72±0.17)μg·L-1

P<0.01)]; serum levels of GAS in the SQ granules 4 g·kg-1 group and SQ granules 2 g·kg-1 group were significantly lower than that in the model group[(68.07±11.38)

(62.42±10.19)

(74.85±7.06) ng·L-1

P<0.05 or P<0.01)]. Conclusion: SQ granules improve mucosal atrophy possibly by increasing serum levels of GH

EGF and reducing serum levels of GAS in rats with chronic atrophic gastritis.