Objective: To investigate the effect of the compatibility of Polygoni Cuspidati Rhizoma et Radix and Astragali Radix

Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba on glucose

lipid metabolism and blood rheology in diabetic nephropathy rats. Method: Diabetic nephropathy was induced by streptozotocin(STZ) peritoneal injection with a dose of 60 mg·kg-1(the normal control group was excluded).Based on fasting blood-glucose(FBG) the rats were randomly divided into 4 groups:model group

Kaibotong group

Polygoni Cuspidati Rhizoma et Radix and Astragali Radix group

Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba group. The drugs were given to rats daily for 8 consecutive weeks. At the end of the 2nd

4th

8th week

the rats were fasted after the last administration and then collected the blood samples

glucose oxidase(GOD) was used to examine the fasting blood glucose

trigluceride(TG)

cholesterol(CHO)

low-density lipoprotein cholesterol(LDL-C)

high-density lipoprotein cholesterol(HDL-C) were also tested

the blood rheology indexes were detected. Result: Compared with the model group

the treatment group could effectively restore the condition of diabetic nephropathy rat

the compatibility of Polygoni Cuspidati Rhizoma et Radix and Astragali Radix

Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba could significantly reduce the levels of blood sugar and blood lipid

the difference was statistically significant (P<0.05 and P<0.01)

andcould change the whole blood viscosity and plasma viscosity of the diabetic nephropathy rats

the difference was statistically significant (P<0.05 and P<0.01). Conclusion: Different compatibility of Polygoni Cuspidati Rhizoma et Radix demonstrates hypoglycemic and hypolipidemic effects

and can reduce the whole blood viscosity and plasma viscosity.