Objective: To investigate regulation of Jinxin oral liquid on expression of interferon-α(IFN-α) in BALB/c mouse infected by respiratory syncytial virus(RSV). Method: BALB/c mice were divided into 24

72 h and 144 h groups

which were infected with RSV after 24

72

144 h respectively and then collected the bronchoalveolar lavage fluid(BALF) to detect the content of IFN-α with Sandwich ELISA assay. Result: IFN-α expression(385.38±16.54)ng·L-1 was increased significantly(P<0.01) in BALF of RSV infected BALB/c mice after 24 h

Jinxin prevention group could increase the expression of IFN-α. After 72 h the increased IFN-α expression in Jinxin prevention group was still significant(32.83±4.77)ng·L-1 (P<0.01)

but compared with 24 h group

the IFN-α expression was decreased obviously. Jinxin treatment group could increase IFN-α expression(131.41±6.96) ng·L-1

(P<0.01). In 144 h group IFN-α expression still had a higher expression

which was lowered significantly compared with 24

72 h group. In 144 h group IFN-α expression(14.21±0.80) ng·L-1 decreased in Jinxin treatment group (P<0.01). Conclusion: In the early stages of BALB/c mice infected with RSV

Jinxin oral liquid prevention and treatment group can significantly increase IFN-α expression

and along with the infection prolonged

IFN-α expression was dropped

Jinxin oral liquid can further lower its expression level.