白虎承气汤解热作用有效部位群的筛选

张超云; 黄显章; 郝鹏飞; 毛秉豫

doi:10.11653/syfj2013120212

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白虎承气汤解热作用有效部位群的筛选

更新时间：2024-01-04

- 白虎承气汤解热作用有效部位群的筛选
- Screening the Effective Parts from Baihu Chengqi Tang on Antipyretic Effect
- 中国实验方剂学杂志 2013年19卷第12期页码：212-215
- 作者机构：
- 作者简介：
- 基金信息：
  
  南阳市科技发展规划项目(2011NYKJ029)
- DOI：10.11653/syfj2013120212
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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张超云, 黄显章, 郝鹏飞, 等. 白虎承气汤解热作用有效部位群的筛选[J]. 中国实验方剂学杂志, 2013,19(12):212-215.

ZHANG Chao-yun, HUANG Xian-zhang, HAO Peng-fei, et al. Screening the Effective Parts from Baihu Chengqi Tang on Antipyretic Effect[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 212-215.
张超云, 黄显章, 郝鹏飞, 等. 白虎承气汤解热作用有效部位群的筛选[J]. 中国实验方剂学杂志, 2013,19(12):212-215. DOI： 10.11653/syfj2013120212.

ZHANG Chao-yun, HUANG Xian-zhang, HAO Peng-fei, et al. Screening the Effective Parts from Baihu Chengqi Tang on Antipyretic Effect[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 212-215. DOI： 10.11653/syfj2013120212.

摘要

目的: 初步筛选白虎承气汤解热作用的有效部位群。方法: 筛选健康大鼠104只

随机分为13组

即A

G2组

每组8只

其中A组为正常对照组。B1

G1组分别ip脂多糖( LPS)(20 μg·kg-1)

诱发动物发热

造模后2 h

ig给予

G1组大鼠分别用白虎承气汤挥发油部位、石油醚部位、乙酸乙酯部位、正丁醇部位、水部位按20 mL·kg ig(折合生药为18.6 g·kg-1)

B1 组ig等容积的生理盐水

并于ip LPS后2

8 h时测量体温。B2

G2组分别sc 20%干酵母混悬液(10 mL·kg-1)

诱发动物发热

造模后3 h

ig给予C2

G2组大鼠分别用挥发油部位、石油醚部位、乙酸乙酯部位、正丁醇部位、水部位按20 mL·kg-1灌胃(折合生药为18.4 g·kg-1)

B2组ig等容积的生理盐水

并于注射酵母菌混悬液后3

9 h时测量体温。并通过上述方法对5个不同提取部位进行药效学筛选。结果: 白虎承气汤正丁醇部位和水部位对发热大鼠具有显著解热效果(P<0.05)

并能持续5 h

而挥发油部位、石油醚部位、乙酸乙酯部位对此作用不显著。结论: 初步排除挥发油部位、石油醚部位和乙酸乙酯部位

并初步确定白虎承气汤解热作用的有效部位群为正丁醇部位和水部位。

Abstract

Objective: To screen the effective parts from Baihu Chengqi Tang for antipyretic effect. Method: The rats were allotted into 13 groups as following:A (normol group)

the first rat febrile models was induced by injecting lipopolysaccharide(LPS

20 μg·kg-1) intraperitonealy and treating with five parts from Baihu Chengqi Tang (18.6 g·kg-1) after two hours. The second rat febrile models were induced by injecting 20% fresh yeast subcutaneously 10 mL·kg-1 and treating with five parts from Baihu Chengqi Tang after two hours. Then the rectal temperature was monitored to show the differences of effect from those groups. Result: Butanol and water fractions could reduce the rectal temperature of the rat febrile models(P<0.05);essential oil and petroleum ether and ethyl acetate fractions could not reduce the rectal temperature of the rat febrile models. Conclusion: The results show that essential oil and petroleum ether and ethyl acetate fractions were invalid

butanol and water fractions were the effective of Baihu Chengqi Tang for antipyretic effect.

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