Objective: To study pharmacological effect of Shufeng Ningtong capsule (SNC) on gout. Method: Rat paw edema model was induced by injection of 1% carrageenan in footpad. SNC of 0.06

0.018

0.006 g·kg-1 (ig 7

15 d) was given to the model rats

and effect on paw thickness was investigated and analyzed. Gouty nephropathy model in rat was established by adding 5% oxonic acid potassium and uric acid 1% (15 g each rat) in the limited feed for 24 d. Mouse model of hyperuricemia was induced by yeast. Blood uric acid level was monitored at 11 d and 24 d. Pain threshold at 7

15 d in mice was determined by using hot plate method and writhing reaction.SNC dose in mice were 0.1

0.03

0.01 g·kg-1. Result: Rat footpad swelling induced by carrageenan was antagonized by SNC (0.06

0.018 g·kg-1) after 7-15 d. SNC (0.1

0.03 g·kg-1) showed significant analgesic effect in mice. SNC (0.06

0.018 g·kg-1

11

24 d) could significantly inhibit oxonic acid potassium induced rat hyperuricemia uric acid level. SNC (0.1

0.03 g·kg-1

15 d) could significantly decrease hyperuricemia uric acid in mouse model induced by yeast. Conclusion: SNC has good therapeutic effect on gout.