Objective: To investigate the therapeutic effects of Qianbai Biyan tablet and its main ingredients on allergic rhinitis in mice. Method: BALB/c male mice were administrated with 200 μL ovalbumin (OVA

0.5 g·L-1) and aluminium hydroxide (20 g·L-1) on the first

fourth

seventh day of the experiment. Starting from the 22nd day

each mouse was poured with 20 μL OVA (50 g·L-1) by nasal drip for 10 days consecutively

but physiological saline instead of OVA in control group. Take 50 modeling successful mice to divide into five groups randomly

the allergic rhinitis model group were nasal drop 10 μL OVA solution (50 g·L-1) and Qianbai Biyan tablet group (17.2 g·kg-1·d-1)

chlorogenic acid group (260 mg·kg-1·d-1) and ρ-coumaric acid (30 mg·kg-1·d-1) group were administrated orally in 10 minutes prior to OVA infusion. Meanwhile

the positive drug group were treated with dexamethasone 5 mg·kg-1·d-1 by subcutaneous injections in 30 minutes prior to OVA administration

and the control group were drop with saline continuously. Immunoglobulin E(IgE)and histamine in serum were detected and the nasal mucosa of mice was evaluated by pathological observation. Result: Qianbai Biyan tablet

chlorogenic acid and dexamethasone could obviously inhibit the typical symptoms of allergic rhinitis

including sneezing

scratched nose and thin or watery nasal discharge and so on. Moreover

the nose mucosa membrane hyperemia

dropsy and the inflammatory damage induced by allergic rhinitis were all reduced

and the increase of IgE and histamine level in the serum was decreased. Conclusion: Qianbai Biyan tablet is effective for the treatment of allergic rhinitis

and chlorogenic acid may be the one of active ingredients of Qianbai Biyan tablet.