Objective: To abserve the effects of Shanmai capsules on blood pressure and myocardial hypertrophy in renovascular hypertensive rats induced by 'two-kidney one-clip'method. Method: Renovascular hypertensive models were established in rats by ‘two-kidney one-clip' method

then the rat models successfully established were chosen by noninvasive blood pressure measurement system and randomly divided into model group(normol saline

NS)

the high

middle

low dose group of shanmai capsules(1.8

0.9

0.45 g·kg-1

respectively)

captopril group(7 mg·kg-1) and normal control group(NS)

were all orally for 4 weeks. The blood pressure of rats were measured before

and after modeling as well as at the last day of drug delivery. Serum and heart specimens of rats were collected at the end of the 4 week to determined the levels of nitric oxide(NO)

angiotensin Ⅱ(Ang Ⅱ)and endothelin(ET). The heart weight(HW)and left ventricular weight(LVW)were measured by precision balance. Remodeling of myocardial fiber diameter(MD)was detected by pathologically method. Result: Shanmai capsules at high dose could reduce the blood pressure(P<0.01)

MD(P<0.01) and the levels of Ang Ⅱand ET in serum(P<0.01)obviously

meanwhile

increased NO (P<0.05). Conclusion: Shanmai capsules could lower the blood pressure of renovascular hypertensive rats

inhibit the formation of myocardial hypertrophy.