Objective: To establish stable hyperlipidemia animal model with self-designed high-fat diet. To evaluate lipid-lowering effect of Shenqi Mixture and investigate lipid-lowering mechanism of Shenqi Mixture. Method: One hundred and twenty SD rats were randomly divided into control group(30)and model group(90).The SD rats of model group were fed with self-designed high-fat diet. Hyperlipidemia models were evaluated successfully by testing four indexes of blood lipids after 10 days. Model rats were divided on lipid level and randomly divided into model group(1 g·kg-1)

Shenqi Mixture group and Simvastatin group(0.001 g·kg-1)(30 each) orally for 20 days. Four indexes of blood lipids and hemorheology indexes were measured and pathological change of liver tissue was observed on 31th day. Result: Four indexes of blood lipid of model SD rats' showed that the hyperlipidemia rats models were successful made on 11th day. The four indexes of blood lipid

hemorheology indexes and pathological change of liver tissue showed that Shenqi Mixture and Simvastatin could decrease total cholesterol(TC)

triglyceride(TG)

low-density lipoproteins cholesterol(LDL-C)and blood viscosity

increase high-density lipoproteins cholesterol(HDL-C)

and alleviate hepatic steatosis of liver tissue on 31th day. The results of TC

HDL-C and hepatic steatosis of liver tissue in Shenqi Mixture group were significant different from Simvastatin group. Conclusion: Stable hyperlipidemia rat model can be established with self-designed high-fat diet. Shenqi Mixture can decrease lipid level and blood viscosity

alleviated hepatic steatosis of liver tissue.