Objective: To investigate the effects of Gegen Qinlian decoction on type 2 diabetes in rats and the dose-effect relationship

to obtain the dosage threshold of the classical prescription. Method: SD rats were randomly assigned into normal control group and diabetic model group

which was established by injection small dose of streptozotosin(STZ) (30 mg·kg-1) after feeding a diet with high glucose and lipids for 4 weeks. Diabetic rats were randomly assigned into model group

dimethylbiguanide group (200 mg·kg-1) and different dose of Gegen Qinlian decoction groups (1.65

4.95

8.25

11.55

14.85

18.15

21.45

24.75

28.05 g·kg-1 accordingly). The serum glucose

insulin

insulin resistance (IR)

glycosylated hemoglobin (HbA1c)

glycosylated serum protein (GSP) were determined. Result: Compared with model group

Gegen Qinlian decoction could decrease serum glucose

insulin

IR

HbA1c and GSP level(P<0.05

P<0.01). As dose of Gegen Qinlian decoction increased

the drug action was more obviously in the specified dose range. The dosage threshold of Gegen Qinlian decoction on diabetes in rats was 27.01-1.09 g·kg-1. Conclusion: The effect of Gegen Qinlian decoction on type 2 diabetes in rats shows fine dose-effect relationship.