Objective: To investigate the protective and curative effects between panax notoginsenoside (PNS) enteric-coated pellets and PNS on experimental atherosclerosis(AS) in rabbits. Method: Fifty rabbits were randomly divided into five groups:blank control group

AS model group

PNS group

Xueshuangtong injection(lyophilization) and PNS enteric-coated pellets.They were administered normal diet+NS

high fat diet+NS

high fat diet+PNS(30 mg·kg-1·d-1

ig)

high fat diet+Xueshuangtong (lyophilization

15 mg·kg-1·d-1

im)and high fat diet+PNS enteric-coated pellets(30 mg·kg-1·d-1

ig) respectively after injecting bovine serum albumin 250 mg·kg-1 on ear vein except blank control group.At the end of 12th week

the blood Lipid was detected by ELISA and the pathological changes of aortic intima was observed under light microscopes. Result: After 12 weeks of administration

PNS group

Xueshuangtong injection(lyophilization) and PNS Enteric-coated pellets could decrease total cholesterol(T-CHO)

triglycerides(TG) and low-density lipoprotein cholesterol(LDL-C) obviously (P<0.01)and increase high density lipoprotein cholesterol(HDL-C)(P<0.01). The levels of T-CHO

TG and LDL-C in Xueshuangtong injection and PNS enteric-coated pellets group were lower than PNS group group(P<0.01)

and HDL-C was much higher(P<0.01). The levels of LDL-C in PNS enteric-coated pellets group was much lower than Xueshuangtong injection group(P<0.01).The morphological observation showed that Xueshuangtong injection and PNS enteric-coated pellets group could alleviate aortic intimal lesions(P<0.01)and there was no difference between them. The effect of PNS enteric-coated pellets was better than PNS group(P<0.01). Conclusion: Both PNS entetic-coated pellet and PNS can decrease blood lipid and aortic intimal lesions of AS rabbits.The prevention effect of PNS Entetic-coated pellet is better than PNS on AS rabbits.