Objective: To explore the anti-inflammatory effect and related mechanism of Sophora tonkinensis granula and its herbal piece. Method: The effect of Sophora tonkinensis granula and its herbal piece (7.0

3.5

1.75 g·kg-1) on carrageenan foot swelling in mice was determined

and the content of proateglandin E2(PGE2) in inflammatory exudate was measured. Tampons induced inflammation in mice was employed

and adrenal weight and vitamin C(Vit C)content were determined. Acute inflammation model was established in mice with lipopolysaccharide(LPS)

and the influence of Sophora tonkinensis granula and its herbal piece on mice serum nitric oxide synthase(NOS)

nitrogen monoxide(NO)

maleic dialdehyde (MDA)

tumour necrosis factor-α (TNF-α) and interleukin-6(IL-6)were determined. Result: Compared with model control group

Sophora tonkinensis granula and its herbal piece in each dose groups all could significantly inhibit foot swelling degree in mice (P<0.05 or P<0.01). Sophora tonkinensis granula and its herbal piece high

middle dose group can inhibit mice granulation weight (P<0.05 or P<0.01). Sophora tonkinensis granula and its herbal piece of high dose group could reduce adrenal Vit C

inflammation foot PGE2 and serum MDA

NO

NOS

TNF-α

IL-6 content (P<0.05 or P<0.01). Conclusion: The anti-inflammatory mechanism of Sophora tonkinensis granula and its herbal piece may be related to its ability of scavenging oxygen free radicals

inhibiting lipid peroxidation reaction

reducing the release of inflammatory cytokines

inhibiting cytokine expression and so on.