Objective: To observe the therapeutic effect of modified formula Rupixiao on mammary hyperplasia rats. Method: Rat models with hyperplasia of mammary glands were established by injection of estradiol benzoate and progesterone. The rats were randomly divided into control group

vehicle group

Rupixiao tablet group (4 g·kg-1) and modified formula Rupixiao groups (8

4

2 g·kg-1). There were 15 rats in vehicle group

and 10 rats in each of other group. The rats were orally administrated with drugs for 9 weeks. The contents of estradiol and progesterone in rat plasma were measured by radioimmunity

and the pathologic examination was carried out on the second and third pairs of breasts after usual fixation and staining. Result: Modified formula Rupixiao 2 g·kg-1 of did not have obvious therapeutic effect on mammary hyperplasia rats. Modified formula Rupixiao 4

8 g·kg-1could not only make the ratio of estradiol to progesterone back to normal(P<0.01)but also improved their pathologic status. Conclusion: Modified formula Rupixiao has conspicuous therapeutic effect on mammary hyperplasia rats.