Objective: To study the clinical effect of Qingzhi capsule combined with atorvastatin tablets in the treatment of hyperlipidemia and its influence for the vascular endothelial function. Method: One hundred and thirty patients with hyperlipidemia were randomly divided into control group and observation group with 65 cases in each group. The control group was treated with atorvastatin tablets

20 mg po. Daily. On the basis of the control group

the observation group was additionally treated with Qingzhi capsule

2 capsules po. tid. Two groups were treated for 8 weeks. Then the total cholesterol(TC)

triglyceride(TG)

low density lipoprotein (LDL-C)

high density lipoprotein (HDL-C)

apolipoprotein A (ApoA) and apolipoprotein B (ApoB) were detected

and the nitric oxide(NO)

von Willebrand factor (vWF) were determined too. Result: The levels of TC

TG

LDL-C and Apo B100 of the observation group after the treatment were all lower than those of control group(P<0.05

P<0.01)

and HDL-C and ApoA1 were higher than those of control group(P<0.05). The total effective rate of observation group was 93.85%

it was better than 81.54% of control group(P<0.05)

while the vWF in the observation group after the treatment was lower than that in the control group. NO was higher than that of control group(P<0.01). Conclusion: Qingzhi capsule combined with atorvastatin tablets can improve the blood lipids in patients

elevate the effectiveness and protect vascular endothelial function.