Objective: To observe clinical curative effect and explore the mechanism of stemona compound eliminate acne ointment in the treatment of acne vulgaris. Method: One hundred and thirty Acne Vulgaris patients were randomly divided into a treatment group and control group. In treatment group the patients washed their face with warm water and applied the stemona compound superfine grinding to the skin lesions in every morning and evening. In the control group the patients would do the same but use benzoyl peroxide gel applied to the skin lesions. Both two groups were treated for 8 weeks. Before treatment and 2

4

6 and 8 weeks after the treatment

the two groups were assessed by acne

pustules

the total lesions reduce rate and adverse reactions

and clinical efficacy was compared in two groups. Result: The effective rate of treatment group 92.30%

control group was 67.26%

significantly better than the control group (P<0.01). The depletion rate of acne

pustules

skin lesions after treatment in the two groups was statistically significant (P<0.05). Among them

the acne treatment depletion rate of the fourth week

sixth week

eighth week was better than control group (P<0.01); the pustules depletion rate of the second week

forth weeks

sixth weeks

eighth week also was better than in control group (P<0.01). Stemona compound eliminate acne ointment has no adverse reaction ointment. Vitro antibacterial acaricidal experiments show that stemona compound eliminate acne ointment on inhibition of pathogenic bacteria of acne is better than that of control group

but also has good killing effect on Demodex mites. Conclusion: Stemona compound eliminate acne ointment in the treatment of acne vulgaris is good

fast

no adverse reaction

and it also have the effect on anti-inflammatory

antibacterial

acaricidal.