Objective: To explore influence of compound Danshen injections combined with Naloxone on head on oxidative stress and inflammatory factor neonatus with hypoxic-ischemic encephalopathy(HIE). Method: One hundred and two cases with HIE were randomly assigned into two group

the cases in control group were treated by conventional therapy and cases in treatment group were treated by compound danshen injections combined with naloxone at the base of conventional therapy

superoxide dismutase(SOD)

malondialdehyde (MDA)

nitric oxide (NO)

glutathione peroxidase (GSH-Px)

interleukin (IL)-6

high sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor (TNF-α) were measured at treatment before and treatment for seventh days.NBNA grade was compared. Result: compare before

MDA

NO

IL-6

hs-CRP

TNF-α both groups decreased significantly

SOD

GSH-Px level both two groups increased significantly at seventh days(P<0.05-P<0.01)

indices change in treatment group was significantly better than those in the control group(P<0.05). After 14

28 d after therapy

the neonatal behavioral neurological assessment (NBNA) score at treatment group was higher than that at control group significantly (P<0.05). Conclusion: The treatment of compound Danshen injections combined with naloxone can inhibit inflammatory reaction and oxidative stress

improving the nerve function.