Objective:To prepare resveratrol hydroxypropyl-β-cyclodextrin(HP-β-CD)inclusion compound and investigate effect of 4 kinds of penetration enhancers on percutaneous absorption of this inclusion cream. Method: Resveratrol HP-β-CD inclusion compound was prepared with lyophilization technique

entrapment efficiency of this inclusion compound was investigated by HPLC.Modified Franz diffusion cell was applied to investigate in vitro transdermal absorption behavior of resveratrol HP-β-CD inclusion compound cream with isolated mouse skin as barrier and chose the best penetration enhancer. Result: Prepared resveratrol HP-β-CD inclusion compound was in high entrapment efficiency.There was large difference when different transdermal enhancers or different concentrations of enhancers were used

1% azone was optimum penetration enhancers. Conclusion: Resveratrol HP-β-CD inclusion compound had high stability

prepared cream with 1% azone as penetration enhancers had the best transdermal permeation behavior

resveratrol HP-β-CD inclusion compound cream had a great development prospect in the beauty.