Objective:To optimize extraction technology of Huayu Qutan granules by central composite design-response surface methodology. Method: Effective parts of Huayu Qutan granules was extracted by decoction

with the content of salvianolic acid B as index

extraction times

ratio of solid to liquid and extraction time as independent variables

nonlinear mathematic models were used to estimate the relationship between independent and dependent variables

response surface analysis were delineated according to these mathematic models

and optimum technology conditions were selected. Result: Optimum extraction technology was as following:extracted 3 times with 10 times the amount of water

1.5 h each time.RSD between the measured value(1.027%) and the theoretical value(1.029%) of the content of salvianolic acid B was small. Conclusion: Central composite design-response surface methodology was successfully used to optimize extraction technology of compounds

optimized technology was stable and feasible

established mathematical model had good predictability.