注射用活血通络制剂的冷冻干燥工艺优选

徐桂红; 林夏; 曹苗苗; 黄道省; 王正宽; 吴建雄; 萧伟

doi:10.11653/syfj2013130025

您当前的位置：

首页 >

文章列表页 >

注射用活血通络制剂的冷冻干燥工艺优选

更新时间：2024-01-04

- 注射用活血通络制剂的冷冻干燥工艺优选
- Optimization of Freeze Drying Technology for Huoxue Tongluo Preparation for Injection
- 中国实验方剂学杂志 2013年19卷第13期页码：25-28
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技部重大新药创制项目(2009ZX09313-032)
- DOI：10.11653/syfj2013130025
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
徐桂红, 林夏, 曹苗苗, 等. 注射用活血通络制剂的冷冻干燥工艺优选[J]. 中国实验方剂学杂志, 2013,19(13):25-28.

XU Gui-hong, LIN Xia, CAO Miao-miao, et al. Optimization of Freeze Drying Technology for Huoxue Tongluo Preparation for Injection[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 25-28.
徐桂红, 林夏, 曹苗苗, 等. 注射用活血通络制剂的冷冻干燥工艺优选[J]. 中国实验方剂学杂志, 2013,19(13):25-28. DOI： 10.11653/syfj2013130025.

XU Gui-hong, LIN Xia, CAO Miao-miao, et al. Optimization of Freeze Drying Technology for Huoxue Tongluo Preparation for Injection[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 25-28. DOI： 10.11653/syfj2013130025.

摘要

目的: 优化注射用活血通络冷冻干燥制剂的成型工艺条件

并考察其稳定性。方法: 以冻干成型效果、复溶性、澄明度、芍药苷及阿魏酸含量的综合评分为指标

在单因素试验基础上

通过正交试验考察甘露醇的用量、药液质量浓度、预冻速率对冻干工艺的影响

采用HPLC测定阿魏酸、芍药苷含量。结果: 优选的成型工艺为以5%甘露醇为填充剂

药液中有效成分质量浓度30 g·L-1

预冻速率30 ℃·h-1

制成的冻干粉针剂质量稳定。结论: 优选的处方和冻干工艺稳定可行

可推广于大生产应用。

Abstract

Objective:To optimize molding technology with vacuum freeze drying of Huoxue Tongluo powder for injection

and investigate its stability. Method: With composite score of freeze-dried molding effect

solubility

clarity

the content of ferulic acid and paeoniflorin as index

based on single factor test

effect of dosage of mannitol

liquid concentration

pre-freezing rate on freeze drying technology was investigated by orthogonal design

the content of ferulic acid and paeoniflorin was determined by HPLC. Result: Optimized molding technology was as following:with 5%mannitol as filler

liquid concentration 30 g·L-1

prefreezing rate 30 ℃·h-1

these prepared freeze-dried powder injection had stable quality. Conclusion: Optimized prescription and freeze-drying process was reliable and feasible

it could be used in large-scale production.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

秦艽配方颗粒制备过程中标准汤剂与其不同方法干燥品质量相关性分析

马甲子鲜叶干燥方法及提取工艺参数考察