Objective:To prepare Xiaoer Fuxie topical gel ointments

and establish its quality control standards. Method: Gel ointments was prepared with extract of Fructus Evodiae

Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi as materials

sodium polyacrylate and carbomer as gel skeleton matrix.Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi were identified by TLC.The content of evodiamine was determined by HPLC. Result: Moldability of prepared gel ointments was good with a suitable mechanical strength and adhesion.Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi were detected by TLC

characteristic identification was distinct and highly specific.Evodiamine showed a good linear relationship in the range of 0.05~0.4 μg (r=0.999 9) with an average recovery of 99.3% (RSD 1.01%). Conclusion: This preparation technology was stable and reasonable.This established quality control method was reliable

accurate and specific

which could be used for quality evaluation of Xiaoer Fuxie topical gel ointments.