均匀设计优选维药行气那尼花颗粒挥发油的-环糊精包合工艺

南京; 刘承; 叶晓川; 刘焱文

doi:10.11653/syfj2013130053

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均匀设计优选维药行气那尼花颗粒挥发油的-环糊精包合工艺

更新时间：2024-01-04

- 均匀设计优选维药行气那尼花颗粒挥发油的-环糊精包合工艺
- Optimization of Inclusion Technology for Volatile Oil from Xingqi Na'nihua Granules by Uniform Design
- 中国实验方剂学杂志 2013年19卷第13期页码：53-56
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- DOI：10.11653/syfj2013130053
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- 纸质出版日期：2013
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南京, 刘承, 叶晓川, 等. 均匀设计优选维药行气那尼花颗粒挥发油的-环糊精包合工艺[J]. 中国实验方剂学杂志, 2013,19(13):53-56.

NAN Jing, LIU Cheng, YE Xiao-chuan, et al. Optimization of Inclusion Technology for Volatile Oil from Xingqi Na'nihua Granules by Uniform Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 53-56.
南京, 刘承, 叶晓川, 等. 均匀设计优选维药行气那尼花颗粒挥发油的-环糊精包合工艺[J]. 中国实验方剂学杂志, 2013,19(13):53-56. DOI： 10.11653/syfj2013130053.

NAN Jing, LIU Cheng, YE Xiao-chuan, et al. Optimization of Inclusion Technology for Volatile Oil from Xingqi Na'nihua Granules by Uniform Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 53-56. DOI： 10.11653/syfj2013130053.

摘要

目的: 优化行气那尼花颗粒中挥发油的β-环糊精(β-CD)包合工艺。方法: 采用饱和水溶液法制备行气那尼花颗粒挥发油β-CD包合物。以挥发油包合率和包合物收得率为综合评价指标

采用均匀试验考察挥发油与β-CD的比例、包合温度、包合时间对包合工艺的影响。应用XRD

DSC

UV及TLC对制备的包合物进行表征。结果: 最佳包合工艺为挥发油与β-CD比例1∶11

包合温度60 ℃

包合时间1 h

挥发油包合率达96.84%。表征试验证实

挥发油β-CD包合物已经形成。结论: 行气那尼花挥发油β-CD包合物制备工艺稳定可行

可推广于产业化应用。

Abstract

Objective:To optimize β-cyclodextrin(β-CD) inclusion process of volatile oil from Xingqi Na'nihua granules. Method: β-CD inclusion complex was prepared by saturated aqueous solution method

inclusion process was optimized by uniform design with inclusion ratio of volatile oil and inclusion yield as indexes

taking ratio of volatile oil to β-CD

inclusion temperature and inclusion time as factors

and phase of this prepared inclusion complex was testified by XRD

DSC

UV and TLC. Result: Optimum inclusion process was as follows:ratio of volatile oil to β-CD 1∶11

inclusion temperature at 60 ℃ and inclusion time 1 h.Inclusion ratio of volatile oil was as high as 96.84% under these optimized technology conditions.Validation result showed that inclusion compound had been formed. Conclusion: This optimized inclusion process was simple

stable and applicable to industrial production.

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