Objective:To investigate the inhibitory effects of 17-methoxyl-7-hydroxyl-benzofuran chalcone(YLSC) on platelet aggregation and coagulation function in rats. Method: Fifty SD rats were randomly divided into five groups:control group

aspirin group(10 mg·kg-1) and YLSC groups(2.5

5

10 mg·kg-1). YLSC and aspirin were administrated through sublingual vein for one week.Inhibition rates of platelet aggregation by YLSC in vivo and vitro were determined in the model of platelet aggregation induced by adenosine diphosphate (ADP)

collagen and arachidonic acid(AA).The anticoagulant effect of YLSC was evaluated by using thrombin time(TT)

prothrombin time(PT)

and activated partial thromboplastin time(APTT) assays. Result: Compared with the control group

YLSC could significantly inhibit platelet aggregation induced by ADP and collagen(P<0.05 or P<0.01)

but did not inhibit platelet aggregation induced by AA. YLSC significantly prolonged the TT and APTT in a dose-dependent manner(P<0.05 or P<0.01). Wereas

YLSC did not show significant prolonging effect in PT assays. Conclusion: YLSC can exert remarkable effects against platelet aggregation and coagulation.