Objective:To research the effect of Wendan decoction[It was made up of Pinelliae Rhizoma

Poria

Bambusae Caulis in Taenias

Aurantii Fructus Immaturus

Citri Reticulatae Pericarpium

Glycyrrhizae Radix et Rhizoma Prasparata Cum Melle.]on superoxide dismutase(SOD)

malondialdehyde(MDA)

nitric oxide(NO) and protein kinase(PKC) in rats serum with schizophrenia. Method:Fifty SD rats were randomly divided five groups: normal group(A)

model group(B)

Wendan decoction high-dosage group(C)

Wendan decoction medium-dosage group(D) and Wendan decoction low-dosage group(E)

ten rats in each group. Before established the model

the C

D

E groups were given Wendan decoction (40

20

10 g·kg-1) and the A and B groups were given normal saline every day

which last for 21 days. After two hours at the last given Wendan decoction or saline

the B

C

D

E groups were ip given MK801 0.6 mg·kg-1 to establish rat schizophrenia the model at the left side of the rat abdominal cavity. After general condition of rats was observed three days

the rats were sacrificed and serum was tested. The superoxide dismutase(SOD)

malondialdehyde(MDA)

nitri oxide(NO) in rats serum were detected by biochemical methods and the PKC in rats serum was detected by double antibody clip ELASA method. Result:Compared with B group

general condition of rats was improved

the MDA

NO

PKC content of group C

D and E were significantly decreased (P <0.05 or P <0.01) and their SOD was significantly increased (P <0.05 or P <0.01)

pathological damage caused by oxygen free radical was alleviated. The PKC content of group C

D and E were significantly decreased (P <0.05 or P <0.01). Conclusion:Wendan decoction could reduce the pathologic lesions of rat with schizophrenia

protect from the damage caused by oxygen free radicals; Wendan decoction could decrease PKC content and thus play a regulatory role in the function of GJIC.