Objective:To probe into the relationship between combined medication and safety of Danhong injection

and offer a reference for clinical medication. Method: Multi-center and large sample hospital centralized monitoring method was applied to study the combined medication among 10 409 inpatients who used Danhong injection. The related data were mined and analyzed. Result: Among all inpatients investigated

the rate of combined use of Danhong injection and chemical drugs was 99.7%. Drugs frequently combined with Danhong injection were cardiovascular and cerebrovascular medicine

psychotherapeutic drug

enteral and parenteral nutrition and regulation water

electrolyte

acid-base balance drug and endocrine drug. The adverse reactions of Danhong injection positive correlated with stomatological preparation

anti-rheumatic and orthopaedic drug

enteral and parenteral nutrition and regulation water

electrolyte

acid-base balance drug and dermatologic drugs. Conclusion: Adverse reactions of Danhong injection related to the types and quantity of combined drugs. Safety monitoring of Danhong injection should be enhanced when it is combined with other drugs.