Objective:To observe the influence Bushen Tongluo fang on diabetic peripheral neuropathy (DPN) oxidative stress. Method: Fourty-eight DPN patients were randomly divided into 2 groups

30 cases in treatment group and 18 cases in control group

two groups were given conventional treatment and lipoic acid for 90 days

in the same time the treatment group were given Bushen Tongluo fang. The clinical curative effect and changes of blood sugar

haemoglobin A1c (HbA1c)

triglyceride (TG)

total cholesterol(CHOL)

nerve conduction velocity

malondialdehyde (MDA)

superoxide dismutase (SOD) were observed. Result: After treatment

the total effective rate of treatment group was 83.3%

and the placebo group was 66.7%. Between the two groups

the difference was significant (P<0.05). The levels of fasting blood glucose(FBG)

HbA1c

TG

CHOL in two groups were significant declined than before (P<0.05)

and TG

CHOL declined was better in treatment group than control group (P<0.05). After treatment

motor nerve conduction velocity(MNCV)

sensory nerve conduction velocity(SNCV) in two groups were obviously improved than before (P<0.01

P<0.05)

and the improvement in treatment group was better than control group (P<0.01). After treatment

MDA was markedly reduced (P<0.01) and SOD obviously improved (P<0.01

P<0.05) in two groups

and the effect in treatment group was better than control group (P<0.01). Conclusion: Bushen Tongluo fang on the basis of conventional treatment and lipoic acid in the treatment of DPN patients can improve the clinical curative effect

improve lipid metabolism

reduce oxidative stress reaction and improve nerve conduction velocity.