Objective:To study the therapeutic effect of Shenling Baizhu powder on chronic otitis media with effusion (OME) in a spleen deficiency type. Method: Sixty patients of OME in a spleen deficiency type were included in the trial.The patients were randomLy divided into experimental group

drug treating group

and 30 healthy people were included as control group.After one course of treatment (14 days)

to test the serum concentration of interleukin(IL)-4

IL-6 and interferon-γ(IFN-γ) of each group by ELISA

and to compare the clinical efficacy of each group. Result: ①experimental group had a better therapeutic effect than drug treating group(P<0.05);②compared to control group

both experimental group and drug treating group had lower serum concentration of IFN-γ and higher concentration of IL-4

IL-6(P<0.01);③after one course of treatment(14 days)

the serum concentration of IL-4

IL-6 had been downregulated

IFN-γ had been upregulated

experimental group was surperior to drug treating group. Conclusion: Shenling Baizhu powder had a significantly clinical efficacy on chronic otitis media with effusion in a spleen deficiency type

and can media the immune response

so it is worthy to promote it being used widely.