Objective:To observe the treatment effects and safety of Bushen decoction with moxibustion of temperature sensitive acupoint on sterility due to anovulation

and to explore the mechanism of action of the treatment in curing sterility. Method: Sixty patients with sterility due to anovulation were randomly divided into two groups

the treatment group (30 cases) took the Bushen decoction with moxibustion of temperature sensitive acupoint

while the control group (30 cases) took Bushen decoction only. They were continuously treated for three months

and then tested basal body temperature (BBT)

and using trans-vaginal ultrasound to test the follicle diameter and thickness of uterine endometriums

and made detection of follicle stimulating hormone (FSH)

luteinizing hormone (LH)

estradiol2 (E2)

prolactin (PRL)

testosterone (T) in serum. The pregnancy rate within 1 year was also investigated. Result: An efficiency of 90% in the treatment group was significantly better than 60% in the control group (P<0.05). The total efficiency of traditional Chinese medicine syndromes of the treatment group was 70% better than 43.33% of the control group ( P<0.01). The pregnancy rate of the treatment group was 63.33% better than 26.67% of the control group ( P<0.05). In treatment group the follicle diameter and endometrial thickness were increased and better than those of the control group( P<0.01). BBT recovery rate was 70% in treatment group better than 33.33% in control group ( P<0.01). FSH

LH and E2 of the treatment group were significantly increased more than those in the control group ( P<0.05). Conclusion: The therapy of Bushen decoction with moxibustion of temperature sensitive can improve anovulatory infertility with regulated hormone levels

prompting BBT recovery

improving clinical symptoms

and increasing pregnancy rate.