Objective:To investigate the effect of treatment of infant recurrent respiratory infection (RRTI) with combination of traditional Chinese medicine and Western medicine. Method: Ninety RRTI patients were randomly divided into observation group and control group (n=45 each). At attack stage

the two groups were received routine western medicine therapy. At remission stage

control group was orally received transfer factor oral solution

10 mL once daily

and observation group was orally treated with Huangqi Shengmai yin

10 mL twice daily and Shenlin Baizhu powder

1 agent daily (taken half by half). The treatment course of two groups was 8 weeks

and follow-up time lasted 6 months. Score of lung and spleen deficiency syndrome was observed

T-cell subsets and immunoglobulin were tested before and after treatment. Result: The total effective rate of observation group (97.77%) was higher than that of control group (66.66%) with a significant difference (P<0.01). The improvement of CD3+

CD4+

CD8+ and CD4+/CD8+ in observation group were better than those in control group (P<0.05

P<0.01). After treatment

IgG and IgA in observation group were increased significantly than those in control group (P<0.01). The syndrome score of lung and spleen deficiency in observation group were significantly lower than those in control group (P<0.01). Conclusion: Western medicine therapy

used at attack stage

combined with Huangqi Shengmai yin and Shenlin Baizhu powder

used at remission stage can improve physical condition of infected children

promote patient immunity

reduce clinical symptom and treat infant recurrent respiratory infection effectively.