响应面分析法优化吴茱萸中去氢吴茱萸碱的提取工艺

邹弢; 杨家强

doi:10.11653/syfj2013140059

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响应面分析法优化吴茱萸中去氢吴茱萸碱的提取工艺

更新时间：2024-01-04

- 响应面分析法优化吴茱萸中去氢吴茱萸碱的提取工艺
- Optimization of Extraction Technology of Dehydroevodiamine from by Response Surface Methodology
- 中国实验方剂学杂志 2013年19卷第14期页码：59-61
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- DOI：10.11653/syfj2013140059
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- 纸质出版日期：2013
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邹弢, 杨家强. 响应面分析法优化吴茱萸中去氢吴茱萸碱的提取工艺[J]. 中国实验方剂学杂志, 2013,19(14):59-61.

ZOU Tao, YANG Jia-qiang. Optimization of Extraction Technology of Dehydroevodiamine from by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 59-61.
邹弢, 杨家强. 响应面分析法优化吴茱萸中去氢吴茱萸碱的提取工艺[J]. 中国实验方剂学杂志, 2013,19(14):59-61. DOI： 10.11653/syfj2013140059.

ZOU Tao, YANG Jia-qiang. Optimization of Extraction Technology of Dehydroevodiamine from by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 59-61. DOI： 10.11653/syfj2013140059.

摘要

目的: 通过响应面分析法对吴茱萸中去氢吴茱萸碱的提取工艺进行优化。方法: 以去氢吴茱萸碱提取率为指标

采用单因素试验和响应面分析法考察药材粉碎度、液料比、乙醇体积分数、提取时间对去氢吴茱萸碱提取率的影响。结果: 最佳提取工艺条件为粉碎度90目

加18.73倍量65.22%乙醇提取0.82 h

去氢吴茱萸碱提取率达6.97 mg·g-1。结论: 采用响应面分析法优化吴茱萸中去氢吴茱萸碱提取条件是合理可行的

为吴茱萸的质量控制提供实验依据。

Abstract

Objective: To optimize extraction technology of dehydroevodiamine(DHED) from Evodia rutaecarpa by response surface methodology. Method: With yield of DHED as index

single factor tests and response surface methodology were adopted to investigate effect of crushed mesh of drugs

solid-liquid ratio

the concentration of alcohol and extraction time on yield of DHED. Result: Optimum extraction technology of DHED was as following:crushed degree of E. rutaecarpa 90 mesh

extracted 0.82 h with 18.73 times the amount of 65.22% ethanol

and yield of DHED was up to 6.97 mg·g-1. Conclusion: It was feasible to optimize extraction technology of DHED from E. rutaecarpa by response surface methodology

it could provide basis for quality control of E. rutaecarpa.

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