Objective: To optimize formulation technology of total flavonoids from Bidens bipinnata sustained release tablets. Method: With hydroxypropyl methyl cellulose K4M (HPMC-K4M) as skeleton materials

starch and lactose as fillers

cumulative release of total flavonoids at three time points as comprehensive evaluation index

based on single factor tests

orthogonal test was used to investigate effect of the amount of HPMC-K4M

starch-lactose

tablets hardness and the amount of anti-adhesion on formulation technology. Result: Optimum prescription of total flavonoids from B. bipinnata was as following:the amount of HPMC-K4M 50%

starch-lactose (2:1)

tablets hardness 5 kg·mm-2

the amount of anti-adhesion(gum acacia) 2%. Conclusion: This optimized technology was stable and feasible

these prepared sustained-release tablets had good granulation

tabletting and sustained release

which were in line with relevant regulations.