Objective: To compare pharmacokinetics of danshensu(DSS) and ferulic acid(FA) in different combinations to GuanxinⅡ

and to reveal the effect of the combination to GuanxinⅡ on the process in vivo of the two main effective components. Method: Beagle dogs were administrated orally with Guanxin Ⅱin combination with different drugs:total extraction recombination

part extraction recombination propitious to blood

danshen extraction recombination

part extraction recombination propitious to breath

ligusticum wallichii extraction recombination.The plasma concentration of DSS and FA were assayed by LC-MS/MS after administration.the pharmacokinetic parameters were estimated by DAS 2.0 phamacokinetic software edited by SUN Rui-yuan

and then to compare pharmacokinetic parameters within different groups by statistic software SPSS 10.0. Result: The statistic results have showed that the pharmacokinetics of combination with different drugs to GuanxinⅡhave no significant difference

but the tendency. Conclusion: The process of danshensu and ferulic acid in vivo (Beagle dogs)are not significantly different.