Objective: The effects of the Blumea balsamifera oil on percutaneous absorption of albuterol sulfate were studied. Then

a theoretical basis for the application of B. balsamifera oil was proved. Method: The effects of six different penetration enhancer programs on albuterol sulfate transdermal absorption were determined

i e

0.5%

1.0%

2.0% B. balsamifera oil

1.0% azone

1.0% B.balsamifera oil jointed with 1.0% azone and black control.Concretely

the contents of albuterol sulfate in receiving fluid were determined by UV spectrophotometer using modified Franz diffusion cell device and the excised skin from guinea pig was taken as exoteric permeability barrier. Result: 0.5%

1.0% B. balsamifera oil and 1% azone individually salbutamol sulfate transdermal absorption and storage reservoir showed a significant role in promoting (P<0.05). However

the effect of combination of 1.0% B. balsamifera oil and 1.0% azone on percutaneous penetration was lower than its using alone. Conclusion: With the increase of low concentration of B. balsamifera oil

the transdermal absorption of salbutamol sulfate enhanced. However

high concentration of B. balsamifera oil showed no significant difference.