Objective: To explore the impact of Qigong Kangxian prescription(QF) on Smad 2/3

Smad7 in hepatic fibrosis rats. Method: Sixty SD rats randomly divided into 6 groups

in addition to the normal control group

the other groups were intraperitoneally injected with 0.5 mL pig's serum twice per week for 8 weeks

the rat hepatic fibrosis model was induced. Rats were given corresponding herbal medicines. After the end of experiment

serum samples were collected. Determination of the content of transforming growth factor was carried out by using ELISA method. Sections of liver tissue was fixed in 10% formaldehyde solution

and then embedded in paraffin

Under the light microscope. Expression of liver tissue TGF-β1

Smad2

Smad3

Smad7 was detected by immunohistochemical method. Result: In the Content of TGF——β1 and expression of liver tissue TGF-β1

Smad2

Smad3 and Smad7 the significant differences were found in administration groups compared with the model group(P<0.01). Conclusion: QF can suppress hyperplasy of hepatic fibrous connective tissue

lessen hepatic injury through decreasing Smad 2/3 expression and increase Smad7 expression.