地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD, CAT和GSH-Px及MDA的影响

宫健伟; 叶蕾; 张秀丽; 樊巧玲

doi:10.11653/syfj2013140247

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地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD, CAT和GSH-Px及MDA的影响

更新时间：2024-01-04

- 地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD, CAT和GSH-Px及MDA的影响
- Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats
- 中国实验方剂学杂志 2013年19卷第14期页码：247-250
- 作者机构：
- 作者简介：
- 基金信息：
  
  山东省高等学校科技计划项目(J12LM54)
- DOI：10.11653/syfj2013140247
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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宫健伟, 叶蕾, 张秀丽, 等. 地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD, CAT和GSH-Px及MDA的影响[J]. 中国实验方剂学杂志, 2013,19(14):247-250.

GONG Jian-wei, YE Lei, ZHANG Xiu-li, et al. Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 247-250.
宫健伟, 叶蕾, 张秀丽, 等. 地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD, CAT和GSH-Px及MDA的影响[J]. 中国实验方剂学杂志, 2013,19(14):247-250. DOI： 10.11653/syfj2013140247.

GONG Jian-wei, YE Lei, ZHANG Xiu-li, et al. Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 247-250. DOI： 10.11653/syfj2013140247.

摘要

目的: 揭示地黄饮子抗脑缺血再灌注损伤的作用机制。方法: 将SD大鼠60只随机分为6组

即假手术组、模型组、阳性药尼莫地平组(1 mg·kg-1)和地黄饮子高、中、低(32

8 g·kg-1)剂量组

每组10只

用药7 d后造模。通过双侧颈总动脉结扎法制作SD大鼠脑缺血再灌注模型

观察地黄饮子对大鼠脑缺血再灌注120 min后血清、脑组织超氧化物歧化酶(S0D)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)活力及丙二醛(MDA)含量的影响。结果: 模型组大鼠血清、脑组织SOD

CAT和GSH-Px活性明显降低

MDA含量明显增加

地黄饮子能显著抑制模型大鼠血清、脑组织中SOD

CAT和GSH-Px活力的降低及MDA含量的升高。结论: 地黄饮子可通过减轻自由基损伤、提高脑组织抗氧化能力达到抗脑缺血再灌注损伤的作用。

Abstract

Objective: To explore the mechanism of Dihuang Yinzi in ameliorating the damage induced by cerebral ischemia-reperfusion. Method: Sixty SD rats were selected and randomly divided into six groups:sham group

model group

Dihuang Yinzi high

medium

low dose group(32

8 g·kg-1) and nimodipine positive drug group(1 mg·kg-1)

each group include 10 rats. The cerebral ischemia-reperfusion model was established after 7 days drug administration. The activities of superoxide dismutase(SOD)

catalase (CAT)

glutathione peroxidase (GSH-Px) and the content of malonaldehyde(MDA) in the serum and brain of rats were observed at 120 min after the cerebral ischemia-reperfusion. Result: The activitis of SOD

CAT and GSH-Px were lower and the contents of MDA were higher in serum and brain of mode1 rats than normal rats.Dihuang Yinzi could increase the activitis of SOD

CAT and GSH-Px and decrease the content of MDA. Conclusion: Dihuang Yinzi can ameliorate the oxidative damage induced by cerebral ischemia-reperfusion.

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