Objective: To investigate the effect of water extracts from Momordica charantia on blood lipid in mouse model of hyperlipidemia. Method: The hyperlipidemia mouse model was induced by high fat diet successfully and the mice were randomly divided into 4 groups:high(30 g·kg-1) and low(10 g·kg-1) dose group of water extracts from M. charantia

L-carnitine(1 g·kg-1)and model group

10 mice in each group. Another 10 normal mice were used as the control group. After treatment of 4 weeks by gastric gavage

serum total cholesterol (TC)and triglyceride(TG)levels were measured by automatic biochemical analyzer. Liver index was calculated and pathological changes of liver tissue were observed by hematoxylin-eosin(HE) staining. Result: Serum TC

TG and liver index of drug groups were significantly reduced after treatment. TC

TG and liver index in high dose group was (2.78±0.33)

(0.90±0.13) mmol·L-1

(0.034±0.002) g·g-1;those in low dose group was (3.87±0.08)

(1.03±0.09) mmol·L-1 and (0.040±0.005) g·g-1. Compared with model group of (4.86±0.34)

(1.43±0.06) mmol·L-1and (0.057±0.007)g·g-1

there were statistical differences (P<0.01

P<0.05). The HE staining results showed that water extracts from M. charantia could significantly reduce the liver fat content of hyperlipidemic mice. Conclusion: Water extracts from M. charantia can evidently decrease blood lipids.