Objective: To explore the effect of Upper middle lower generic gout decoction in the treatment of hyperuricemia. Method: Hyperuricemia rat model was established by administration of adenine and ethambutol

ig

for 21 days. High

middle

low dose groups were given upper middle lower generic gout decoction 5

10

20 g·kg-1continuously for 21 days

ig respectively. The concentration of uric acid (UA)

xanthine oxidase (XOD)

adenosine deaminase (ADA)

blood urea nitrogen (BUN)and creatinine (Cre) were detected in serum. Result: The content of UA of high

middle

low dose groups were (188.99±20.82)

(202.56±19.77)

(226.53±29.83) μmol·L-1respectively

which was significantly lower than those of the model group (310.12±22.23) μ mol·L-1

(P<0.05)

also distinctly lower than that of allopurinol group (P<0.05). The XOD content of middle group was (40.15±0.74) U·L-1

which was significantly lower than that in the model group (49.19±1.61) U·L-1

(P<0.05). ADA content of high and middle dose groups (24.02±0.32)

(28.61±1.78) U·L-1

respectively were obviously lower than those in the model group (34.36±3.73) U·L-1

(P<0.05). Both BUN and Cre content of all the three dosage groups were significantly lower than those in the model group(P<0.05). Conclusion: Upper middle lower generic gout decoction show better anti-hyperuricemia effect

and also significantly reduce the BUN level and downregulate the production of UA

meanwhile

it exerts protective effects on the kidney.