Objective: To investigate hormonal profile and metabolic abnormalities in subgroups of women with polycystic ovary syndrome(PCOS) and explore a reasonable classification for PCOS. Method: Two hundred and thrity-five PCOS patients were recruited and divided into subgroup according to their body mass index(BMI)and homeostasis model assessment (HOMA-IR)

serum sexual hormone

insulin

sugar metabolism

serum lipid levels were analyzed. Result: ① The level of testosterone(T)

fasting plasma glucose(FPG)

fasting insulin (FINS)

2 hour fasting insulin(2 h-INS)

triglyceride (TG)

low density lipoprotein cholesterol (LDL)of the obese PCOS group were higher than those of the Non-obese PCOS group

while the level of follicle stimulating (FSH)

luteinizing hormone(LH)

high density lipoprotein cholesterol (HDL) were lower than the Non-obese PCOS group

all the differences were significant (P<0.05);② body mass index(BMI)

fasting plasma glucose(FPG)

fasting insulin(FINS)

2 h-plasma glucose (2 h-PG)

2 h-INS

TG

HDL were higher than that of the group without insulin resistance

luteinizing hormone(LH)

high density lipoprotein cholesterol (HDL) were lower than that of the group without insulin resistance

all the differences were significant (P<0.05). Conclusion: ① The non-obese PCOS patients were characterized by hypothalamus-pituitary gland-ovary (HPO) axis dysfunction

the obese PCOS patients are easier to present insulin resistance;② there is a metabolic disturbance in patients with PCOS

which is more obvious dyslipidernia in obese and insulin-resistant patients.