Objective: To explore the effect and mechanism of Zhishi Xiebai Guizhi decoction on matris metalloproteinases-9(MMP-9)

tissue inhibitor of metalloproteinase(TIMP-1) levels and gene expression in patients with blood stasis

sputum

qi stagnation

cold obstruction unstable angina (UA). Method: Sixty UA patients were divided into control group(30)and treatment group(30) randomly. ELISA was used to determine the serum MMP-9

TIMP-1 levels. Real time fluorescent quantitative PCR was used to determine MMP-9

TIMP-1 gene expression. Compared the serum MMP-9

TIMP-1 levels and gene expression from the two group. Result: The two groups had significant improvements in Symptom integra after treatment(P<0.05)

and the treatment group were superior to the control group(P<0.05).The two groups had significant improvements in Serum levels of MMP-9

TIMP-1 after treatment(P<0.05).and the treatment group were superior to the control group(P<0.05). The two groups had significant improvements in MMP-9

TIMP-1 mRAN after treatment(P<0.05). The treatment group were superior to the control group in MMP-9/TIMP-1mRAN(P<0.05). Conclusion: Based on the standardization of treatment

Zhishi Xiebai Guizhi decoction can improve the serum MMP-9

TIMP-1 levels and gene expression in patients with blood stasis

sputum

qi stagnation

cold obstruction UA

and advance the stability of atherosclerosis plaque.