益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响

张佩江; 郭建中

doi:10.11653/syfj2013140314

您当前的位置：

首页 >

文章列表页 >

益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响

更新时间：2024-01-04

- 益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响
- Effect of Yiqi Huayu Lishui Decoction on Vascular Endothelial Growth Factor and Urinary Albumin Excretion Rate in Patents of Early Diabetic Nephropathy Combined with HIV/AIDS
- 中国实验方剂学杂志 2013年19卷第14期页码：314-317
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省医学科技攻关计划省部共建项目(2011010016)
- DOI：10.11653/syfj2013140314
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
张佩江, 郭建中. 益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响[J]. 中国实验方剂学杂志, 2013,19(14):314-317.

ZHANG Pei-jiang, GUO Jiang-zhong. Effect of Yiqi Huayu Lishui Decoction on Vascular Endothelial Growth Factor and Urinary Albumin Excretion Rate in Patents of Early Diabetic Nephropathy Combined with HIV/AIDS[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 314-317.
张佩江, 郭建中. 益气化瘀利水方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响[J]. 中国实验方剂学杂志, 2013,19(14):314-317. DOI： 10.11653/syfj2013140314.

ZHANG Pei-jiang, GUO Jiang-zhong. Effect of Yiqi Huayu Lishui Decoction on Vascular Endothelial Growth Factor and Urinary Albumin Excretion Rate in Patents of Early Diabetic Nephropathy Combined with HIV/AIDS[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 314-317. DOI： 10.11653/syfj2013140314.

摘要

目的: 探讨益气化瘀利水复方对HIV/AIDS合并糖尿病肾病患者血管内皮生长因子(VEGF)及尿蛋白排泄率(UAER)的影响。方法: 56例HIV/AIDS合并糖尿病肾病患者随机按数字排列法分为治疗组和对照组各28例

两组均进行抗病毒、降糖等西药常规治疗

治疗组给益气化瘀利水复方(当归芍药散合防己黄芪汤)

口服

1剂/d

疗程3个月。采用酶联免疫吸附试验(ELISA)检测VEGF水平;放射免疫法检测尿白蛋白

计算UAER。结果: 治疗组血清VEGF水平较治疗前明显下降(P<0.01)

UAER较治疗前明显下降(P<0.01)

且治疗组优于对照组(P<0.01)。结论: 益气化瘀利水复方可降低HIV/AIDS合并糖尿病肾病患者血清VECG水平

同时降低UAER

是其保护肾功能的可能作用机制之一。

Abstract

Objective: To explore the effect of Yiqi Huayu Lishui decoction (YQHYLSD) on vascular endothelial growth factor (VEGF) and urinary albumin excretion rate (UAER) in patents of early diabetic nephropathy combined with HIV/AIDS. Method: Fifty six cases of early diabetic nephropathy combined with HIV/AIDS were randomly divided into two groups. Two groups were received routine western medicine treatment and antivirus. The treatment group was treated with YQHYLSD one dose daily for 3 months. The levels of plasma VEGF in the two groups were measured by immunohistochemisty and enzyme linked immunosorbent assay. The urinary albumin excretion was measured to calculate UAER. Result: The plasma levels of VEGF and UAER in treatment group were significantly lower then those of control group

and the outcome in treatment group was more effective then that in the control group(P<0.05). Conclusion: VECG and UAER play an important role in the pathogenesis of early diabetic nephropathy patients combined with HIV/AIDS. YQHYLSD can degrade VEGF and UAER levels of early diabetic nephropathy patients

which is one of possible mechanism of YQHYLSD protecting the renal function.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

益气通痹合剂抗胶原诱导的关节炎大鼠关节滑膜血管新生作用的研究

健脾活血方对激素性股骨头坏死血管内皮生长因子表达的影响

滋阴地黄丸对兔眼脉络膜组织中 VEGF,bFGF和PEDF表达的影响