Objective: Through the systematic collection of ancient and modern drugs in treatment of ulcerative colitis to summarize the ancient and modern used effective drugs and analysis of medicine laws including compare drug trends between ancient and modern medicine. Method: The ancient and modern prescriptions were collected and SPSS 11.5 statistics software was applied to establish a database

so as to summarize medicine laws depending on correlation analysis

frequency analysis and cluster analysis as well as difference between ancient and modern medicine made by student t test. Result: A total of 461 the ancient prescription and 286 the modern prescription collected. Licorice

angelica

ginger

wood

poria et al of ancient high-frequency medicine and licorice

woody

poria

dried tangerine peel

Magnolia et al of modern high-frequency were showed by frequency analysis. The significant positive correlation between the medicine were showed by correlation analysis. UC prescription medicine compatibility relations were further pointed out by cluster analysis. A significant difference between ancient and modern UC drug trends was showed by student t tests. Conclusion: The ancient prescriptions are applied to supplement Qi and blood

invigorate spleen and stomach deduced by the statistical data. While

the modern prescriptions are applied to replenish lung and spleen Qi

clear heat and remove dampness detoxification

promote blood circulation and remove blood stasis

harmony Qi and purge stagnation

spleen and stomach

invigorate spleen and stomach. There was significant difference between ancient and modern medicine trends.