To analyze effective methods for improving and enhancing the bioavailability of the active ingredients in the traditional Chinese medicine (TCM). On the basis of summarizing and analyzing the biopharmaceutical and pharmacokinetic characteristics of osthol

the main active ingredient of fructus cnidii

pharmaceutical methods and components compatibility are proposed to have influence on the bioavailability and disposition of osthol. Osthol

as a poorly water soluble drug

had a good permeability

but bioavailability was poor. Pharmaceutical methods and components compatibility are helpful to improve the poor bioavailability of osthol. To improve and enhance the bioavailability of the active ingredients in the TCM

we can not only resort to pharmaceutical methods

but also the reasonable application of components compatibility between the TCM.