Objective: To observe the efficacy of combined therapy of Jiawei Zuojin pill and triple therapy for gastric ulcer (GU) and the influence on trefoil factor (TFF2) and epidermal growth factor (EGF). Method: 80 patients with GU (the stagnated heat syndrome in the liver and stomach) were randomly divided into treated group (n=40) and control group (n=40). Patients in the control group received triple therapy

that is Omeprazole Enteric-coated capsules Azithromycin (20 mg

two times per day)

Clarithromycin Capsules (0.5 g

two times per day) and Amoxicillin capsules (0.5 g

two times per day

oral). Jiawei Zuojin pill (6 g

two times per day) combined with triple therapy was administrated to patients in the treated group. The course is last for 4 weeks. The score of stagnated heat syndrome in the liver and stomach

eradication rate of Helicobacter pylori (HP)

efficacy of endoscopy and TFF2 and EGF levels in Serum were observed. Result: The score of stagnated heat syndrome in the liver and stomach in the treated group was significantly lower than that of control group(P<0.01). Ulcer area of treatment group (0.17±0.21)cm2 was significantly lower than that of control group(P<0.05).There was no significant difference in total efficiency between treated group (97.5%) and control groups (92.5%).Curative effect of TCM syndromes in the treated group were significantly better than the control group(P<0.01). Eradication rate of HP of the treated group(84.8%) was better than that of the control group (67.6%)(P<0.01). After treatment

TFF2 and EGF levels in treatment group were significantly higher than that of the control group

though levels of the two cytokines in both group increased. Conclusion: Jiawei Zuojin pill can significantly improve the curative effect of triple therapy for gastric ulcer

the mechanism may be related to the increasing of TFF2 and EGF.