Objective: To investigate the clinical efficacy of compound matrine injections intrapleural perfusion combined with Fuzhenxiaoshui-prescrip oral in the treatment of malignant pleural effusion. Method: Eighty-seven patients with malignant pleural effusion were divided into the control group of 43 cases and the observation group 44 cases according to random number. Central venous drainage placed in pleural was used in the two groups. Cisplatin was intrapleurally injected in the control group. The observation group was treated with the compound matrine injection and Fuzhenxiaoshui-prescrip oral besides cisplatin intrapleural injection. Course of treatment was three weeks. The amount of pleural effusion was monitored. Quality of life in patients was evaluated. Clinical symptoms and signs and adverse reactions were recorded. Result: Remission rate (CR+PR) of the observation group was 84.1%

which was higher than 58.13% of the control group (P<0.01). The quality of life of the observation group was improved compared with the control group (P<0.05). Clinical symptoms and signs

such as dyspnea

cough and chest pain of the observation group was significantly improved compared with the control group (P<0.05). The number of cases of chest pain and gastrointestinal reactions of the observation group was significantly less than the control group (P<0.05). Conclusion: On the basis of conventional Western medicine treatment

compound matrine injections intrapleural perfusion combined with "Fuzhenxiaoshui-prescrip" oral

can increase the clinical efficacy of malignant pleural effusion

improve the patient's quality of life

and reduce the side effects of chemotherapy. Therefore

it is worth to be widely used clinically.