Objective: To systematically evaluate the efficacy of Shegan Mahuang decoction versus western medicine on cough variant asthma in children. Method: Pubmed

CNKI

VIP

WanFang Data were researched for the randomized controlled trials(RCTs) of Shegan Mahuang decoction for cough variant asthma in children. Two reviewers evaluated the quality of the included RCTs and extracted data criticallyand independently

and then the extracted data were analyzed by using RevMan 5.1 software. Result: Eight RCTs involving 850 patients entered the inclusion criteria. The results of meta-analyses showed that compared with Western medicine treatment

Shegan Mahuang decoction could increase the total effective rate [OR=5.24

95%CI(3.51

7.83)

P<0.000 01];Shegan Mahuang decoction could decrease the total content of tumor necrosis factor-α(TNF-α) [SMD=-1.26

95%CI(-2.37

-0.15)

P=0.03]

significant differences. Conclusion: The current evidence shows that Shegan Mahuang decoction is effective in treatment cough variant asthma in children

and can significantly reduce the content of tumor necrosis factor-α(TNF-α.) However

the quality of methodology and report of small sample of RCT is lower

and the curative effect of Shegan Mahuang decoction needs to be approved further by strict designed clinical trials with large sample.