大孔树脂纯化红花中羟基红花黄色素A的产业化探索

吴建雄; 秦建平; 万琴; 王振中; 萧伟

doi:10.11653/syfj2013160005

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大孔树脂纯化红花中羟基红花黄色素A的产业化探索

更新时间：2024-01-04

- 大孔树脂纯化红花中羟基红花黄色素A的产业化探索
- Preliminary Exploration of Industrialization for Purification of Hydroxysafflor Yellow A from by Macroporous Resin
- 中国实验方剂学杂志 2013年19卷第16期页码：5-7
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技部"重大新药创制"项目(2011ZX09401-097)
- DOI：10.11653/syfj2013160005
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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吴建雄, 秦建平, 万琴, 等. 大孔树脂纯化红花中羟基红花黄色素A的产业化探索[J]. 中国实验方剂学杂志, 2013,19(16):5-7.

WU Jian-xiong, QIN Jian-ping, WAN Qin, et al. Preliminary Exploration of Industrialization for Purification of Hydroxysafflor Yellow A from by Macroporous Resin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 5-7.
吴建雄, 秦建平, 万琴, 等. 大孔树脂纯化红花中羟基红花黄色素A的产业化探索[J]. 中国实验方剂学杂志, 2013,19(16):5-7. DOI： 10.11653/syfj2013160005.

WU Jian-xiong, QIN Jian-ping, WAN Qin, et al. Preliminary Exploration of Industrialization for Purification of Hydroxysafflor Yellow A from by Macroporous Resin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 5-7. DOI： 10.11653/syfj2013160005.

摘要

目的: 优选D101大孔树脂纯化红花中羟基红花黄色素A的工业化放大工艺。方法: 采用HPLC测定羟基红花黄色素A含量

通过单因素试验考察上样液pH、洗脱剂体积分数和用量、药材-树脂质量比对纯化工艺的影响

通过中试及工业化生产验证优选的纯化工艺。结果: 优选的纯化工艺条件为上样液pH 4.0

药材-树脂质量比1:6

加4 BV水以3 BV·h-1的流速洗脱除杂

用5%乙醇6 BV以3 BV·h-1的流速洗脱

收集洗脱液。结论: 该工艺简单可行、分离效果好

适用于羟基红花黄色素A的大生产。

Abstract

Objective: To optimize industrialization amplification process for purification of hydroxysafflor yellow A from Carthamus tinctorius by macroporous resin. Method: The content of hydroxysafflor yellow A was determined by HPLC

single factor tests were adopted to investigated effects of pH of sample solution

the concentration and amount of eluant

quality ratio of raw materials to resin on purification technology

then verified optimized technology through pilot and industrialization production. Result: Optimum purification conditions were as follows:ratio of crude drug to D101 resin 1: 6

pH of sample solution 4.0

eluted impurity with 4 BV water at flow rate of 3 BV·h-1

then eluted with 6 BV 5% ethanol at 3 3 BV·h-1

collected eluent. Conclusion: This technology was simple and feasible with good separation

it could be suitable for industrialized production of hydroxysafflor yellow A.

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