气相色谱法测定甘油中杂质乙二醇与二甘醇的含量

赵鑫; 肖玉平; 黄荣林; 黄碧云

doi:10.11653/syfj2013160171

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气相色谱法测定甘油中杂质乙二醇与二甘醇的含量

更新时间：2024-01-04

- 气相色谱法测定甘油中杂质乙二醇与二甘醇的含量
- Determination the Content of Ethylene Glycol and Diethylene Glycol in Glycerol Samples Using Gas Chromatography
- 中国实验方剂学杂志 2013年19卷第16期页码：171-174
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- DOI：10.11653/syfj2013160171
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- 纸质出版日期：2013
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赵鑫, 肖玉平, 黄荣林, 等. 气相色谱法测定甘油中杂质乙二醇与二甘醇的含量[J]. 中国实验方剂学杂志, 2013,19(16):171-174.

ZHAO Xin, XIAO Yu-ping, HUANG Rong-lin, et al. Determination the Content of Ethylene Glycol and Diethylene Glycol in Glycerol Samples Using Gas Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 171-174.
赵鑫, 肖玉平, 黄荣林, 等. 气相色谱法测定甘油中杂质乙二醇与二甘醇的含量[J]. 中国实验方剂学杂志, 2013,19(16):171-174. DOI： 10.11653/syfj2013160171.

ZHAO Xin, XIAO Yu-ping, HUANG Rong-lin, et al. Determination the Content of Ethylene Glycol and Diethylene Glycol in Glycerol Samples Using Gas Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 171-174. DOI： 10.11653/syfj2013160171.

摘要

目的: 采用气相色谱(GC)法测定甘油样品中乙二醇与二甘醇的含量。方法: 色谱柱为键合6%氰丙基-96%二甲基聚硅氧烷的毛细管柱(DB-624)

采用程序升温方式

内标法进行定量。结果: 乙二醇、二甘醇检测质量浓度在20.00~160.00 mg·L-1样品峰面积与内标峰面积比值与浓度线性关系良好

乙二醇线性回归方程为YEG=0.004X-0.025(r=0.999 8)

平均回收率101.80%

RSD 1.6%;二甘醇线性回归方程为YDEG=0.004 2X-0.045 7(r=0.999 8)

平均回收率98.95%

RSD 1.9%。结论: 方法简单、出峰时间短

可以更好地用于甘油的质量控制。

Abstract

Objective: A gas chromatographic (GC) method for ethylene glycol and diethylene glycol determination in glycerol samples was established. Method: 6% cyanopropyl-phenyl and 94% dimethyl polysiloxane capillary column (DB-624) was used. The internal standard method with temperature-programmed mode was used for quantitative analysis. Result: The sample peak area and the internal standard peak area ratio to the concentration of samples for both the ethylene glycol and the diethylene glycol had a good linear relation in the range of 20.00-160.00 mg·L-1. The linear equation of ethylene glycol was YEG=0.004X-0.025 (r=0.999 8). The average recovery was 101.80% and RSD was 1.6% (n=9).The linear equation of diethylene glycol was YDEG=0.004 2X-0.045 7 (r=0.999 8). The average recovery was 98.95% and RSD was 1.9% (n=9). Conclusion: The method has a short peak retention time

which can be used for quality control of the glycerol.

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