Objective: To study the effect of Xinfukang(XFK)oral liquid on MM isoenzyme of creatine kinase(CK-MM) mRNA and CK-MM protein expression level in rat of heart failure model after myocardial infarction. Method: The rat heart failure mode after myocardial infarction was created by ligating the left anterior descending coronary arteries. All the rats were randomly divided into 4 groups:sham group

model group

XFK 5.4 g·kg-1 group and captopril 0.1 g·kg-1 group. After 24 hours of modeling

rats were ig given XFK and captopril for 4 weeks

Cardiac function

myocardial ultrastructure and key enzymes of myocardial energy shuttle

CK-MM mRNA and protein expression level were separately measured in all groups. Result: ①Compared with model group

in captopril group and XFK group CK-MM mRNA and protein expression increased (P<0.01). ②Compared with captopril group

in XFK group CK-MM mRNA expression level decreased (P<0.05). In XFK group CK-MM protein expression has no significant change. Conclusion: XFK oral liquid can effectively increase the expression level of CK-MM mRNA

as well as the protein content of CK-MM to improve myocardial energy shuttle and remodel the process of myocardial energy metabolism function.