Objective: To study the effect and mechanism of Tianshu capsule on the migraine's mice

which was composed of Gastrodiae Rhizoma and Ligustici Chuanxiong Rhizoma. Method: Model was building on ICR mice after subcutaneous injection of reserpine 0.1 mg·kg-1·d-1×12 d

control group mice were injected 0.9% sodium chloride injection

treatment were started on the seventh day of modeling for 6 consecutive days

dose were 1.55

4.65 g·kg-1. The pain threshold was tested on the twelve day

the clotting time was tested next day and concentration of serotonin (5-HT)

noradrenaline(NA) in the brain.was detected. Zolmitriptan tablets were used as a positive durg. Result: Compared with model group

the tianshu capsule could increase the pain threshold(P<0.01)

prolong the clotting time(P<0.01)

increase the concentration of 5-HT and NA in brain(P<0.05

P<0.01). Compared with positive drug

the capsule could increase the concentration of 5-HT(P<0.05). Conclusion: The capsule can treat the migraine's mice by balancing release of 5-HT

inhibiting vascular dilatation of migraine attacks.