Objective: To study the protection effect of Polygonatium sibiricum polysaccharide(PSP) on cisplatin-induced hepatotoxicity. Method: Forty Sprague-Dawley rats were randomly divided into normal control group

model group

the low dosage group

the middle dosage group and the high dosage group of PSP

with eight rats in each group. The model rats with hepatotoxicity were duplicated with injection of cisplatin(5 mg·kg-1). The rats were injected with cisplatin(5 mg·kg-1) after fifth days rats in the low

middle and high dosage group of PSP were treated by PSP 10

20

40 g·kg-1 once a day. After 10 days of administration with PSP

the changes of liver coefficient were examined and the blood alanine aminotrans ferase(ALT)

aspartate amino transferasen(AST)

the activity of superoxide dismutase(SOD)

glutathione peroxidase(GSH-Px) and the content of malondialdehyde(MDA) was measured. Result: Compared with the normal control group

contents of ALT

AST in serum were significantly increased in each treatment group(P<0.01)

the content of MDA was significantly increased(P<0.01) and the activity of SOD and GSH-Px was significantly decreased(P<0.01). Compared with the model group

contents of ALT

AST in serum were significantly decreased in each treatment group(P<0.05 or P<0.01)

the content of MDA was significantly decreased(P<0.05 or P<0.01) and the activity of SOD and GSH-Px was significantly increased(P<0.05 or P<0.01). Conclusion: PSP may improve the function in liver injury rats induced by cisplatin and inhibite the oxidative damage of liver.