Objective: To observe the therapeutic effect of Qingre Jiedu decoction (QJD) and find the bacteriological mechanism on septic model in rats. Method: The septic model was induced by cecal ligation and puncture. The experimental rats were divided into three groups:control group

septic model group and QJD (24 g·kg-1) treated group. The survival and the bacterial populations of ascites and blood in experimental sepsis treated with QJD were determined by bacterial culture and real time PCR. Result: The populations of conditioned pathogen such as Escherichia coli and Staphylococcus aureus in QJD treated group were decreased significantly compared with that of model group(P<0.01). Conclusion: Conditioned pathogen may be primary pathogen of septic rats in our study. QJD are contribute to improve survival in septic model by suppressing proliferation of conditioned pathogen.