Objective: To compare the pharmacological effect of three Sijunzi Tang adopted different processing technology. Method: The pharmacodynamic differences for three decoctions of Sijunzi Tang processed by different technics were compared

using two kinds of spleen-deficiency model. One model was induced by Pendulifory Elshortzia. The rats were randomly divided into the model group

the blank control group

Sijunzi Tang groups with high

medium and low doses (10

5

2.5 g·kg-1)

Sijunzi Tang adopted the high pressure processing with high

medium and low doses (10

5

2.5 g·kg-1)

Sijunzi Tang adopted the atmospheric pressure processing with high

medium and low doses (10

5

2.5 g·kg-1)

and cisapride as the positive control group. The other model was induced by reserpin. The mice were randomly divided into the model group

the blank control group

Sijunzi Tang adopted the traditional decoction processing with high

medium and low doses (13.2

6.6

3.3 g·kg-1)

Sijunzi Tang adopted the high pressure processing with high

medium and low doses (13.2

6.6

3.3 g·kg-1)

Sijunzi Tang adopted the atmospheric pressure processing with high

medium and low doses (13.2

6.6

3.3 g·kg-1).Xiangsha Yangwei pills were used as positive control. The criteria included general physical signs

D-xylose excretion rate

amylase activity

serum gastrin content and indexes of organs determined before and after treatment. Result: After treatment with Sijunzi Tang

the spleen symptoms of spleen-deficiency animals were improved

and the final data analysis showed that Sijunzi Tang could significantly improve spleen-deficiency symptoms. The indicators showed that Sijunzi Tang adopted the traditional processing was slightly better than that adopted the machine processing. However

there was no significant difference among the three Sijunzi Tang adopted different processing technics for the therapeutic effect on the spleen-deficiency animals. Conclusion: The three processing technics of Sijunzi Tang show similar therapeutic effect for the spleen-deficiency animals.